Biginelli Reaction of Aliphatic Aldehydes Catalyzed by α-Chymotrypsin: One-Pot Biocatalytic Synthesis of Dihydropyrimidinones

One-Pot Multi-Component Synthesis of Dihydropyrimidinones via Biginelli Condensation

Three-component reactions have emerged as useful methods because the combinationof three components to generate new products in a single step is extremely economical,among the multi-component reactions. A green, simple, efficient, and cost-effective procedure has been carried out by the synthesis of dihydropyrimidinonesin Biginelli’s condensation of ethyl cyanoacetate, aldehyde and urea or thio...

CuCl2 Catalyzed Solvent-free One Pot Synthesis of Dihydropyrimidinones

one-pot multi-component synthesis of dihydropyrimidinones via biginelli condensation

0

Enantioselective One-Pot Synthesis of α-Amino Esters by a Phosphine-Catalyzed [3+2]-Cycloaddition Reaction

Phosphine-catalyzed [3+2]cycloaddition reactions of electron-deficient allenes and alkynes with a,b-unsaturated carbonyl compounds can give access to important highly functionalized cyclopentenes. The seminal example of such a transformation was first reported by Lu et al. in 1995, and its asymmetric version in 1997 by the group of Zhang. However, it took another ten years before the potential ...

Cobalt(II) chloride catalyzed one-pot synthesis of α-aminonitriles

A simple and efficient method has been developed for the synthesis of alpha-aminonitriles by a one-pot three- component condensation of aldehydes, amines, and potassium cyanide in acetonitrile in the presence of a catalytic amount of CoCl2 at room temperature.